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TOPIC: Antipsychotics Triple Risk of Type 2 Diabetes

Antipsychotics Triple Risk of Type 2 Diabetes 28 Aug 2013 16:55 #266

Antipsychotics triple risk of type 2 diabetes in young people
Posted August 22, 2013 by Michele G. Sullivan

Antipsychotic medications appear to triple the risk of type 2 diabetes in children and teens, with most of the risk occurring in the first year of administration.

A retrospective study of more than 43,000 youths found the same threefold increase, no matter how the data were analyzed, Dr. William V. Bobo and his colleagues reported in the Aug. 21 online edition of JAMA Psychiatry (JAMA Psych 2013 [doi:10.1001/jamapsychiatry.2013.2053]).

The risk translated into an additional 15.8 cases of type 2 diabetes per person-year of antipsychotic treatment, with a number needed to harm of 633, wrote Dr. Bobo of Vanderbilt University in Nashville, Tennessee, and his associates.

The investigational cohort consisted largely of Medicaid enrollees, ’which limits the generalizability of study findings, given that the incidence of type 2 diabetes in children covered by Medicaid may be elevated owing to economic and social factors, as well as to a greater prevalence of behavioral risk factors, disability, and chronic illness.’


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